Mesotherapy Cocktails

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Filorga NCTF 135 HA -
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Filorga NCTF 135 HA is the perfect /mesotherapy/ for individuals requiring more intense revitalization and repair of loose, tired skin, deep wrinkles and redensification of mature or slack skin. There has been 10 years of success in treating over one million patients with this highly effective anti-aging therapy. NCTF 135HA is a concentrated formula, with 200x more active ingredient than NCTF 135. Treatment areas include:


BCN Mesoceuticals - Click here for detailed info

 An international company specialising in mesotherapy

At Institute BCN we are experts in mesotherapy. BCN provide physicians and health and beauty professionals throughout the world with the widest range of mesoceuticals on the market, and the equipment necessary to apply the most advanced needle free mesotherapy treatments.

BCN offer efficient, safe and scientifically proven cosmetic solutions, the result of years of continued research and development. Non-invasive treatments which are painless, with no side effects and offering immediate results which allow us to provide effective and customised solutions for cosmetic problems of both the face and body, such as ageing skin, localised fat, skin spots, hair loss, flaccid skin, cellulite, stretch marks, acne or scars.

From our beginnings, Institute BCN has had a clear international vocation. Thanks to a wide distribution network spread throughout the world, our brand currently has a presence in more than 60 countries on five continents.



Filorga NCTF 135 HA is the perfect /mesotherapy/ for individuals requiring more intense revitalization and repair of loose, tired skin, deep wrinkles and redensification of mature or slack skin. There has been 10 years of success in treating over one million patients with this highly effective anti-aging therapy. NCTF 135HA is a concentrated formula, with 200x more active ingredient than NCTF 135. Treatment areas include:
  • Face

  • Neck

  • Décolleté

  • Back of the hands

  • Inside of the arms

  • Inside of the legs

  • Abdomen

Independent testing by a French research centre has yielded amazing results:

  • 90% anti-radical protection (Cellular Protection)

  • 256% collagen synthesis (Redensification)

  • 366% elastase inhibitor gene expression (Regeneration)

The skin texture of participants responded with equally impressive results after being treated with NCTF 135HA:

  • 72% wrinkle and fine wrinkle reduction

  • 103% improvement of tonus

  • 132% improvement of hydration

  • 144% improvement of brightness

NCTF 135HA is formulated with hyaluronic acid as a top active ingredient. Hyaluronic acid is a major component of skin where it is involved in moisturizing and repairing damage. Age and exposure to UVB rays degrade hyaluronic acid production and have a detrimental effect on its continued production. Scientific research has shown that the main active ingredient in NCTF 1353HA is necessary for collagen production and increased cellular proliferation. The medical community is administering hyaluronic acid at an ever increasing rate to aid in tissue repair and achieve anti-aging results. NCTF 135HA uses highly purified hyaluronic acid which is obtained through bio-fermentation with no animal origins, resulting in perfect biocompatibility.

The unique revitalizing formulation of Filorga’s NCTF 135HA is associated with a number of factors that promote wrinkle repair and anti-aging benefits: fourteen vitamins, including A, B, C and E, stimulate vital cell functioning; twenty-four amino acids promote protein production which leads to increased amounts of elastin and collagen; two
anti-oxidants capture free-radicals, leading to greater health and longevity.


BCN Cocktails

The BCN Cocktails products are ingredient combinations perfectly studied and developed in order to take advantage of the synergies between different active principles and increase their effects in face and body. They can be used alone or be combined with other products from both BCN Classics and BCN Cocktails range. They are sterile (no preservatives or additives), so they achieve a great tolerance. They are packed in 10 ml unit dose vials, presentation that facilitates the mixture with other active ingredients.

Also they allow to create 100% customised treatments for each patient in order to effectively fix in a personalised way aesthetic problems such as skin ageing, localised fat, spots, hair loss, flaccidity, cellulite, stretch marks, acne scars, etc.


Click on each product for detailed information:
BCN REVITA-HA-Polyrevitalising Cocktail Hyaluronic Acid, Vitamins, Amino Acids, Minerals, Coenzymes
Revitalises and moisturises tired or dull skins; reduces wrinkles and re-densifies mature and flaccid skins. For Acne, Anti-ageing, Couperose, Hyperpigmentation.
LYPOLYTIC treatment L-Carnitine, Caffeine, Fucus, Ruscus, Organic Silica, Glaucine, Phosphatidylcholine
A product designed to get rid of localised fat deposits from the body contour and abdominal folds, and from the upper arms, thighs, buttocks, knees and waist. It can also be used to get rid of lipomas and in liposuction treatments.
BCN ADIPO Anti-cellulite cocktail L-Carnitine, Caffeine, Fucus, Ruscus, Organic Silica, Glaucine.
A product developed to combat cellulite and restore skin firmness, as well as for use on the face for aesthetic conditions such as double chin.
BCN MELANO - Enlightening Cocktail Glutathione 600, Glycolic Acid, Kojic Acid, Vitamin C, Citric Acid.
Enlightening treatment softens pigmentations on face/body.
BCN BASE Hyaluronic Acid, X-DNA Gel, Organic Silica.
Replenishing Cocktail, Anti-ageing treatment suitable for face, neck, decollete and other dehydrated areas. Acne, Anti-ageing, Couperose, Eye area, hair loss, Hyperpigmentation
Stretch marks and scars.
BCN ECQ10 Elastin, Collagen, Q10.
Regenerative skin treatment for surface areas with ageing sings and striae. Acne, Anti-ageing, Cellulite, Stretch marks and scars


BCN Classics

The BCN Classics products belong to the Institute BCN mesoceuticals range. They are pure active ingredients, pharmaceutical quality formulations meticulously selected. They are sterile (no preservatives or additives), so they achieve a great tolerance. They can be used alone or be combined with other products from both BCN Classics and BCN Cocktails.

Also they allow to create 100% customised treatments for each patient in order to effectively fix in a personalised way aesthetic problems such as skin ageing, localised fat, spots, hair loss, flaccidity, cellulite, stretch marks, acne scars, etc.


Click on each product for detailed information:
Amino Acids Revitalize, regenerate and restructure skin, with increased flexibility and elasticity, more luminous and improved texture.
 Argireline Argireline Anti-Wrinkle Solution combines two active ingredients to achieves a mild, non-toxic Botox effect.
 Artichoke Extract For cellulite & localized fat.
 Asian Centella Regenerative solution, for cellulite, skin rejuvenation, hair loss and stretch marks.
 Biotin Nutritive Solution helps acne & hair loss.
 Caffeine Lipolytic solution, for cellulite, eye area, hair loss.
 Dexpanthenol Nutritive solution, acne, hair loss, stretch marks and scars
 DMAE Firming solution, Anti-ageing, cellulite, stretch marks and scars.
 DNA Liquid & X-DNA gel Anti-Ageing Solution, acne, anti-ageing, hair loss, stretch marks and scars.
 Ginkgo Biloba Anti-Cellulite Solution, for couperosis, eye area, hair loss.
100mg, 600mg & 900 Lyophilized
Anti-Oxidant solution, anti-ageing, hyper-pigmentation, revitalizing serum for tired and ageing skin.
 Glycolic Acid Brightening Solution, Acne, hyperpigmentation, stretch marks and scars. Regenerative skin treatment for surface areas with ageing sings and striae (skin irregularities)
 Hyaluronic Acid 0,8%, 2%, 3.5%. 10% Anti-Ageing Solution, improves wrinkles, highly hydrating.
 Hyaluronidase 1500 UI Anti-Cellulite Solution, stretch marks and scars.
 L-Carnitine Lipolytic solution Anti-Cellulite.
 Organic Silica Regenerating Solution, anti-ageing, anti-cellulite, hair loss, localized fat, improves skin elasticity and tone.
 Organic Silica & DMAE An all-in-one facelift and anti-ageing firming treatment that combines two powerful rejuvenating agents. ,  anti-cellulite, localized fat, stretch marks and scars, improves the elasticity.
 Phosphatidylcholine 5 & 10 Lipolytic Solution. Polyunsaturated Phosphatidylcholine is a liquid form of lecithin.
 Polyvitamins Nutritive Solution, acne, anti-ageing, hair loss, improves the skin appearance.
 Rutin & Melilot Extract Toning Solution, cellulite, couperoses, vascular & facia inflammation. (often used with Vit C).
 Sodium Pyvurate Revitalizing solution for tired and aged skin, anti-ageing, cellulite, hyperpigmentation.
 Trace Elements Good for balancing the skin’s natural functions and maintaining a youthful appearance.
 Vitamin A Nutritive Solution improves the skin appearance, acne, eye area, stretch marks and scars.
 Vitamin C Revitalizing & Anti-Oxidant Solution, Revitalizes skin tone and protects against free radicals. Acne, Anti-ageing, couperose, hyperpigmentation, stretch marks and scars.


BCN Cocktails - detailed info


A product specially developed as integral revitalizing and intense moisturizer, suitable for tired or dull skin, for the treatment of wrinkles and re-densification of mature or flabby skin.
The cocktail BCN Revita-HA brings light, tone, elasticity and firmness to the skin. It contains hyaluronic acid, an essential element for viscoelastic skin balance. It also has vitamins that have an antioxidant effect, are free radicals neutralizers, biological balancers and collagen synthesis boosters. Amino acids are essential elements of the protein synthesized by fibroblasts. Minerals are present in hundreds of enzymatic reactions and essential cellular functions. Finally, co-enzymes increase the speed of skin tissues construction.

The Polyrevitalising Cocktail BCN Revita-HA is a highly moisturizing and revitalizing compound. It contains hyaluronic acid, vitamins, amino acids, minerals and coenzymes. Hyaluronic acid has a hygroscopic action by binding large amounts of water through the creation of water and hydrogen bonds; also helps cell proliferation. Therefore, hyaluronic acid is an essential visco-elastic dermis and epidermis balance item. Vitamin A (retinol) improves flexibility and skin density by regulating keratinisation and healing processes. It also works as dermal antioxidant, destroying free radicals that cause cell and tissue damage.

Vitamin B acts on essential fatty acids metabolism, contributing to biological equilibrium of the skin. Vitamin C neutralizes free radicals, inhibits localized melanin hyperproduction and collagen synthesis, an important protein that strengthens the structural support and the skin elasticity. Vitamin E acts against free radicals by inhibiting hydrogen peroxide. Amino acids exert an action on protein synthesis by fibroblasts. Cells combine these structural elements - fibroblasts- to form proteins, also known as polypeptides.

Collagen is mainly composed of proline, hydroxyproline and lysine. Elastin is mainly composed of aspartic acid threonine and serine. They all are amino acids. Minerals exert an iconic action on several hundred enzymatic reactions and essential cellular functions. As cofactors, minerals improve the different biological metabolisms; as an example, magnesium is involved in 180 enzymatic reactions. The coenzymes, in turn, catalyze the rate of metabolic reaction of the organism, decreasing the amount of energy required for the reactions may occur. Thus, these biochemical activators increase the rate of tissue building.

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LYPOLYTIC treatment
A product designed to get rid of localised fat deposits from the body contour and abdominal folds, and from the upper arms, thighs, buttocks, knees and waist. It can also be used to get rid of lipomas and in liposuction treatments. Phosphatidylcholine dissolves the fat stored in the adipocytes or fat cells, helping to get rid of localised fat deposits. Deoxycholic acid is used in the reduction of localised fat. It is recommended for people who are of normal weight or slightly over, but who have localised areas of fat and for people wishing to optimise and maintain the results of a fat reduction treatment. L-carnitine transports fat from these deposits, releasing it for the metabolism to burn. Organic silicon keeps the epidermis hydrated, firming and strengthening the skin, as well as acting as an antioxidant to actively prevent the acceleration of premature ageing.

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BCN ADIPO Anti-cellulite cocktail
A product developed to combat cellulite and restore skin firmness, as well as for use on the face for aesthetic conditions such as double chin.

L-carnitine and caffeine mobilise accumulated fat, releasing it so it can be burnt by the metabolism. Caffeine also improves the circulation and tightens and tones the skin, reducing the appearance of cellulite. Fucus helps the body get rid of retained fluids, stimulates the circulation and has a detoxifying and draining effect on the oedemas caused by cellulite. Ruscus helps address problems related to blood circulation. Glaucine stimulates lipolysis and inhibits the emergence of new fat cells, which visibly reduces the appearance of “orange-peel skin”, restoring the skin’s firmness. Lastly, organic silica hydrates, renews and regenerates cells and improves the synthesis of collagen.

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BCN MELANO - Enlightening Cocktail
This formula has been carefully developed to correct changes to the skin such as hyperpigmentation and age spots. It prevents photo- ageing, improves acne marks and scarring and gives the skin a more youthful appearance, thanks to its five active principles. Glutathione in high concentration, vitamin C and citric acid as antioxidants for the skin.

Glutathione is also a detoxifying agent and inhibits the synthesis of melanin, an action that works in synergy with kojic acid.

Glycolic acid is used for its exfoliating effect in order to increase the penetration of the other topical agents, at the same time as depositing hydrating agents inside the surface of the newly exfoliated skin, thereby reducing the appearance of fine lines, wrinkles and age spots, and improving sun-damaged skin.

Pigmentation on the skin due to age, sun exposure or disorders such as melasma have led to a need for the development of formulations such as BCN Melano which, thanks to its five active principles, carefully selected for their depigmentation and antioxidant effects, are able to treat these changes to the skin and restore its smooth, even and luminous tone. These five ingredients are glutathione 600, glycolic acid, kojic acid, vitamin C and citric acid.

Glutathione has a high concentration of 600 mg per gram of tissue and, together with vitamin C, makes this product a powerful antioxidant for the skin, reducing the damage caused by free radicals which are a harmful by-product of sunlight, smoke and pollution.

Similarly, glutathione plays an important role in protecting the cell during ageing, acting also as a detoxifying agent and inhibiting the synthesis of melanin. This capacity makes it an essential component in the treatment of melasma, which is nothing more than a hyperpigmentation of the skin, characterised by the presence of irregular patches of light brown to greyish brown colour in the areas of the face exposed to the sun and which can also appear during pregnancy, when taking birth control pills, or among those with dark skin. This last action is strengthened with the presence of kojic acid (5 Hydroxi 2-Hydroximethyl-γ-Pyrone) in the formulation, since this is a powerful inhibitor of the production of melanin, which is why it is also known for its "whitening" effect. It presents the advantage of not staining the skin even when it is exposed to the sun and is not toxic to the cutaneous cells, as is the case with other depigmentation products. Therefore, apart from treating the spots, it gives the skin a more uniform tone and makes it more luminous.

Numerous studies have demonstrated its depigmenting effect after exposure to ultraviolet radiation, equivalent to the effect of a sunscreen (Mishima, Nair and Tramposch et al.) and its beneficial effect on melasma (Mishima Y 1987, Nakayama H et al 1981 and 1982 and Minami K. 1982). Similarly, it is characterised by excellent tolerance, which has also been made clear in the various clinical trials that have been conducted.

Another of the components of BCN Melano is glycolic acid, α-hydroxy acid (AHA), used more frequently. Thanks to its exfoliating effect, it is used to reduce the barrier of the stratum corneum and increase the penetration of the other topical agents, at the same time as stimulating the growth of the skin and collagen. The result is a much smoother skin and a more youthful appearance.

Another advantage of glycolic acid is its capacity to deposit hydrating agents inside the surface of the newly exfoliated skin, reducing the appearance of fine lines and wrinkles, age spots, and improving sun-damaged skin, making it an agent that works in total synergy with the other components of this formula. Vitamin C is a very effective antioxidant which neutralises free radicals, inhibits melanin, stimulates the growth of the hydro lipid film and increases the synthesis of collagen. Its topical use is vital for curing wounds and burns caused by the sun, since it also helps stabilise collagen and repair elastic tissue. It is used in the prevention and treatment of photo-ageing, as well as the appearance of "broken blood vessels".

Finally, citric acid is an organic tricarboxylic acid used habitually in cosmetics for its antimicrobial and antioxidant effect, which contributes to the stability, effectiveness and improved appearance of the final product, as well as adding its antioxidant action to that of the other active principles.

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BCN Base provides the hydration every skin needs and the elasticity that results from it, through the hydrating properties of its three ingredients, especially those of hyaluronic acid.

These effects are maintained if the skin is protected from the impact of free radicals which contribute to ageing. To achieve this, the natural polymer, X-DNA, acts in perfect synergy with the hyaluronic acid and adds an antioxidant effect to the product.

Finally the organic silica renews and regenerates the cells.

BCN Base is the primary product in the BCN Cocktails line since, with its composition of hyaluronic acid, X-ADN and organic silica, it is in itself a basic anti-ageing treatment and at the same time forms the ideal base for mixing with other ingredients to obtain more specialized products that respond to the needs of each skin type. Hyaluronic acid is a highly effective skin moisturizing agent because of its particular ability to attract and retain water molecules and is therefore excellent for treating dry, wrinkled, tired or sun-damaged skins.

The high level of hydration provided by this component results in maintenance of the tissue's elasticity, from the outer surface layers to the deepest layers of the skin. Similarly, it fills the space between the collagen and the elastin fibres, providing a means of transporting essential nutritional substances to the cutaneous cells, contributing to the renewal of the dermis and the elimination of compounds harmful to the skin. It also improves cutaneous vascularisation and is capable of strengthening the skin against ultraviolet radiation, thanks to its anti-free-radical properties. This component makes BCN BASE the ideal base par excellence, through its ability to facilitate the distribution of other agents in the skin.

X-ADN is a natural polymer with an excellent antioxidant and hydrating effect which protects the cell membranes from oxidative damage and stimulates skin healing, thanks to its capacity to restore dead cells and rebuild connective tissue. In perfect synergy with hyaluronic acid, it is capable of improving skin problems such as dry skin, wrinkles and the effects of ageing, as well as improving the appearance and tone of the skin, stretch marks and helping prevent and treat hair loss.

The perfect combination of BCN BASE is complemented by organic silica, a structural element of the connective tissue which hydrates, renews and regenerates cells. It keeps the epidermis hydrated, firming and strengthening the skin, as well as acting as an antioxidant to actively prevent any acceleration of premature ageing. Due to all the benefits that this component provides, it is incorporated into almost all treatments for cellulite, lipolysis, skin renewal, hair loss, stretch marks and wound healing.

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A new product in the BCN Cocktails line which, thanks to collagen, elastin and coenzyme Q10, makes the skin firmer, smoother and more hydrated, giving it a more youthful appearance.

Collagen, a protein of the connective tissue, is responsible for the skin's plumpness and elasticity. With the passage of the years, its fibres become more fragile and are lost, so it is necessary to make up for this lack with synthetic products that stimulate their synthesis and restore the skin's plumpness, fill wrinkles and fight against ageing of the skin.

Elastin, as hydrolysed elastin, is able to recover the skin's elasticity and flexibility and combat its slackness.

Finally, coenzyme Q10 is known for its antioxidant properties. Its continuous application is able to repair skin damage and attenuate the deterioration of collagen. As a result, the skin is strengthened and existing expression lines and wrinkles are reduced.

This product is intended to maintain the effects of natural collagen and elastin, molecules whose quantity diminishes with age. This effect is achieved by providing synthetic collagen and elastin, and at the same time, coenzyme Q10, which attenuates the loss of these molecules, and therefore also combats skin ageing.

Like the other products of the BCN Cocktails line, it can be mixed with other ingredients of the BCN Classics range, to adapt them to each skin type. Collagen is a protein that forms part of the dermal connective tissue and its function is to provide the skin with plumpness and elasticity. With the passage of the years, these fibres become more fragile and become smaller in diameter, resulting in a lack of elasticity and firmness in the skin. This is why the majority of cosmetics aim to regenerate this protein, in order to improve the skin: filling lines and wrinkles and reducing scars or any other structural dysfunction.

Elastin possesses a long chain of amino acids in which there are many sequences with hydrophobic amino acids, separated by other sequences that contain pairs of glycines and other small amino acids, such as lysine. It is this chain of hydrophobic amino acids that gives it its elastic properties, since it allows an arrangement into coiled structures, and lysine participates in the formation of helices, which are the points at which adjacent elastin molecules link together.

These two components, present in the product in hydrolysed form, are able to replace the effects of natural collagen and elastin which are gradually lost with age and they therefore maintain the elasticity characteristic of young skins.

Finally, coenzyme Q10, also known as ubiquinone, is known for its antioxidant properties and ability to inhibit the cell destruction caused by free radicals. Its continuous application is able to repair the damage that these harmful elements have caused to the skin and attenuate the deterioration of dermal collagen. As a result, the skin becomes stronger and more resistant to ageing, at the same time as existing expression

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BCN Classics - detailed info

Amino Acids
Amino acids are natural products, versatile in behaviour and functions. These include the synthesis of new collagen or fibroblasts. Amino Acids Essential Solution includes: Ala, Arg, Asp, Cys, Gln, Gly, His, Ile, Leu, Lys, Phe, Pro, Ser, Tau and Thr.

The result is a revitalized, regenerated and restructured skin, with increased flexibility and elasticity, more luminous and improved texture..

Amino acids are versatile natural products on their behaviour and properties, with a variety of biological functions to fulfil. Among them: water-binding, blocking environ- mental damages, restoring normal structure of the der- mis, acting as antioxidants, improving tissue/hair nutri- tion, stimulating synthesis of new collagen, fibroblasts and keratin, as well as promoting wound-healing.

Water accounts for about 60% of the human body and about a half of the remaining part consists of amino acids. They are integral part of the Natural Moisturizing Factor (N.M.F.), which helps to maintain a healthy skin barrier and to keep it hydrated. It is known that the skin contains more amino acids than any other tissue in the living body.

They are the "building blocks" for all life and also the chemical basis for all proteins. The synthesis of fibrous proteins which are vital for the skin, such as collagen and elastin, can only take place if the necessary biological precursors, the amino acids, are available.

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Argireline - Anti-Wrinkle Solution
Argireline Anti-Wrinkle Solution combines two active ingredients to achieve a mild, non-toxic Botox effect, reducing and preventing expression wrinkles by inhibiting muscle contraction. The perfect Botox alternative for those who do not wish to lose their full range of facial expression.

Argireline Anti-Wrinkle Solution has been proven effective both in reducing existing facial wrinkles and in preventing the development of new lines, directing its formulation to the heart of the very same wrinkle-formation mechanism.

Argireline Anti-Wrinkle Solution is effective for expression lines on the forehead, between the eyebrows, around the eyes and to reduce "bar code" lines on the lips
Inspired by the Mesobotox treatment, this solution combines two ingredients to achieve a mild, non-toxic Botox effect. It reduces and prevents emotional wrinkles by inhibiting muscle contraction.

Faces with more complex expressions and whose overlapping of muscular functioning are a standard contra-indication of the Botox, since this would lead to rather sinking and the general aspect becomes sad. Argireline, acetyl hexapeptide-3 a unique peptide, is a chain of six amino acids that both reduces the degree of existing facial wrinkles and has been demonstrated effective against their development. This solution is a non-toxic, safer and milder alternative to Botulinum Toxin, topically targeting the same wrinkle-formation mechanism in a very different way.

Muscular contraction is attenuated twice by blocking ions entrance with leuphasyl, and modulating the formation of the SNARE complex with argireline.

Muscles are contracted when they receive neurotransmitter released from a nerve cell and Botulinum Toxin A paralyses the muscle by selectively blocking acetylcholine release at the neuromuscular junction. BONT-A cleaves the protein SNAP-25 irreversibly, and therefore the SNARE complex cannot assemble. Argireline is a mimic of the N-terminal end of SNAP-25 and it competes with the natural protein for a position in the SNARE complex, so it destabilizes its formation, without breaking any of its components. If the SNARE complex is slightly destabilized, the vesicle cannot release neurotransmitters.

Leuphasyl, a pentapeptide mimics the natural path of enkephalins, acting on expression wrinkles formation in a new way. It is a modified enkephalin that couples to the enkephalin receptor, outside of nerve cells.

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 Artichoke Extract
Artichoke better know as Cynara scolymus has been used in traditional medicine for centuries as a specific liver and gallbladder remedy.

Artichoke Extract is used to mobilize fatty stores in the liver and detoxify it, and as a natural aid to lower cholesterol. Cynarin demonstrated properties against oxidative stress induced by inflammatory mediators. In addition it exercises a certain control on lipolysis, favouring the synthesis energy-transporting enzymes NAD-NADH2 and NADP-NADPH2. It acts as diuretic and vasoconstrictor, stimulating the lymphatic drainage system.

Artichoke mobilizes fat stores from tissues such as white adipose tissue, and these fats pour into the blood from which they are subsequently excreted from the body.

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Asian Centella
This effective cocktail combines Centella asiatica (Gotu kola), Fucus vesiculosus and Hedera helix extract (Ivy) to improve blood circulation, (particularly in areas where cellulite is present), strengthen the skin and stimulate the connective tissue. The result is Asian Centella, an efficient all-in-one treatment for cellulite, skin rejuvenation, hair loss and stretch marks.

The use of Asian Centella in the management of dermatological conditions has a long tradition and it has a wide range of applications:

Centella asiatica has been documented to aid wound healing in several scientific studies. One of the primary mechanisms of action of this plant appears to be the stimulation of type- 1 collagen production. The triterpenes of Centella Asiatica, and more particularly, asiatic acid, stimulate collagen and elastin biosynthesis, and help to improve wound repair with a better reepithelialisation and a normalisation of perivascular connective tissue allowing an improvement of the venous wall tone and elasticity.

Centella has the potential to enhance connective tissue integrity, elevate antioxidant levels in wound healing, and improve capillary permeability. Asian Centella helps in strengthening the capillaries and veins and assists with better blood circulation. It stops the formation of fibers that trap fat cells in cellulite and improve the flexibility of the connective tissue. Asian Centella, stimulates collagen synthesis by energizing dermal fibroblasts, which leads to stronger blood vessel walls.

Fucus is able to inhibit the inflammatory effects. It has anti-aging properties by increasing skin elasticity and its polysaccharides are natural antioxidants. The thallus of fucus contains organic iodine, which mobilizes retained fluids from some parts of the body, stimulates blood circulation and removes toxins. Edema is one of the agents that cause cellulite; thus, active principles which reabsorb edemas are of great use to treat this condition.

Ivy saponins have demonstrated in vitro anti-elastase and anti-hyaluronidase activities, useful for the protection and for the treatment of vein insufficiency. The stimulating action of ivy saponins on blood circulation is reinforced by the flavonoids in this plant. The main activity attributed to flavonoids is that they act as "vein-active" agents, namely that they reduce the permeability and increase the resistance of blood capillaries. The saponins mixture also showed anti-inflammatory effects.

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Biotin, also known as vitamin H, is a water-soluble B-complex vitamin necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids. Deficiency may include dermatologic symptoms like dermatitis, alopecia (hair loss) and achromotrichia (absence or loss of pigment in the hair).

Biotin is required for the function of acetyl Co-A carboxylase, an enzyme that puts together the building blocks for production of fats. Since the membrane of all cells must contain the proper fat components to function properly, the correct and efficient fat production processes are critical for the health of all cells.

This active substance is a vitamin that helps stimulate cellular repair and promotes healthy skin cell, and tissue growth. It helps against premature hair loss and greying.

Studies have shown that Biotin influences the composition of keratin and promotes the formation of intercellular lipid layers through increased lipid synthesis, which improves the skin's natural barrier function and provides a distinct reduction of fine wrinkles in the skin when applied topically. Overall improvement in skin morphology.

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Caffeine Reducing Solution works to increase blood flow and stimulate adipocytes to release fat into the bloodstream, so that it can to be burned by the body's metabolism. In simple terms, caffeine drains the body's fat cells.
In parallel, Caffeine Reducing Solution tightens and tones the skin, helping to reduce the appearance of cellulite. When applied topically, it works to act as a lipolytic agent, breaking down the fat tissue and causing localized weight loss, without incurring any side effects.

Caffeine is an alkaloid. An alkaloid is defined as any of various nitrogen containing organic bases obtained from plants. Caffeine is one of three types of alkaloids, the others being theophylline and theobromine, found in coffee, tea, cola nuts, cacao beans, mate and guarana. These compounds are methyl xanthines, have different biochemical effects.

Caffeine has a stimulant effect and increases the mobilization of free fatty acids in the blood stream. Caffeine is able to stimulate cell metabolism and specifically promotes the hydrolysis of triglycerides into free fatty acids and glycerol, thus reducing adipose storages. This is particularly useful in the cellulitis phenomenon where, due to an alteration of the microcirculation, adipocytes are stimulated to synthesize and accumulate higher amounts of triglycerides resulting in an increase of the cell size. Caffeine increases lipolysis by inhibiting the cyclic nucleotide phosphodiesterase, which is responsible for catalyzing the conversion of cyclic AMP to AMP. The resulting high tissue concentrations of cyclic AMP activate inactive hormone-sensitive lipase and promote lipolysis.

It has also a diuretic effect, which helps to control the liquid retention associated to cellulitis. Caffeine acts to drain the fat cells, tightens and tones the skin and helps to reduce the appearance of cellulite even more. The diuretic action helps to remove water from fat cells, thereby reducing their size.

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Dexpanthenol Regenerating Solution acts as a moisturizer, boosting moisture levels in the stratum corneum, reducing transepidermal water loss and maintaining the skin's natural softness and elasticity.

Dexpanthenol Regenerating Solution accelerates cellular repair, resconstructs damaged tissue and promotes normal keratinization of the skin and hair.

Panthenol, also called pro-vitamin B5, is a naturally presented in skin and hair. It is part of the coenzima A, necessary for the structure and regeneration of epitelial lipids and of the mucous.

Topical Dexpanthenol acts like a moisturizer, improving stratum corneum hydration, reducing transepidermal water loss and maintaining skin softness and elasticity. Moreover, it activates the fibroblast proliferation and accelerates re-epithelization in wound healing. This substance has been also shown to have an anti- inflammatory effect on experimental ultraviolet-induced erythema. Beneficial effects of Dexpanthenol have been particularly observed in patients who have undergone scar treatment, or therapy for burn injuries and different dermatoses. It is a calming agent.

Panthenol is essential for the normal function of epithelial tissues. Dexpanthenol, applied to the skin and hair, quickly is converted into its bioatcive form vitamin B5 accelerating cell regeneration. It helps repairing damaged tissue and promotes normal keratinization of the skin and hair. Deficiency results in loss and discoloration of hair.

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DMAE - Dimethylethanolamine  acts immediately to improve the appearance of sagging, flaccid skin. Its firming action works by protecting the elastin and collagen cross-links.

DMAE Firming Solution provides an instant face or bodylift effect, while defending the skin against free radicals and simultaneously infusing it with moisture.

DMAE or Norcholine started to be used in external use to produce a lifting effect. It is a natural compound in our body.

DMAE is a precursor of acetylcholine, a neuro-mediator which plays an important role in the skin. Keratinocytes, fibroblasts, myofibroblasts, sweat cells and endothelial cells, have membrane receptors and respond to acetylcholine. The tensile effect of DMAE results in a cholinergic stimulation of membrane receptors of fibroblasts, and stimulates progressive concentration of the myofilaments of its cytosol. DMAE also has antiradical and anti-lipofuscine activities and it repairs the proteinic cross linking (collagen and elastin) of the area.

The mode of action of DMAE can consequently result a synergic combination of actions at different levels: tension of dermal non-muscle cells, cohesion and displacement of keratinocytes, hydration and elasticity of the stratum corneum, better nutrition and skin defences, antioxidation and skin uniformation. It acts quickly and lasts long.

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DNA Liquid & X-DNA Gel
A natural polymer with excellent antioxidant and moisturizing capabilities that protect the cell membranes from oxidative degradation.
Its capacity to restore dead cells and reconstruct connective tissue stimulates the healing processes. Nucleic acid combats collagen destruction caused by sun rays, oxidative stress and tobacco. As well as being used in anti-ageing treatments to fight photo-ageing, X-DNA Gel also enhances the skin of smokers and is able to improve a variety of conditions such as dry skin, wrinkles, stretch marks and hair loss.

DNA is a natural polymer present in the cell nucleus of all living beings, and the origin of the genetic code. Its therapeutic effects increase in proportion to the size of the DNA chain, as high polymerisation makes the product more active and improves tissue penetration.

It has been observed that DNA has the power to restore cells that suffered necrosis, reconstructing connective tissue by stimulating the scarring processes. X-ADN can restore dead cells and reconstruct a new conjunctive tissue stimulating healing processes.

Histologicaly, DNA can turn back the destruction of proteins (basically collagen), blood cells, immuno-competitive structures and restore lesions caused by ischemic processes. Because of its restorative effects on proteins, X-AND Gel acts against collagen destruction by sun rays, oxidative stress and tobacco (free radicals damages). It possesses synergic action with vitamin E.

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Ginkgo Biloba
Gingko's most powerful effect is on the circulatory system. Ginkgo improves blood circulation by widening the micro-capillaries while simultaneously strengthening the vessel walls.

This dual action makes Gingko Biloba Anti-Cellulite Solution ideal for stimulating localized lipolysis and for treating cellulite. In addition to offering wide-ranging anti-ageing benefits, it is also effective in combating hair loss and reducing the appearance of dark eye circles.

Ginkgo biloba is a fossilized tree with a history of use in traditional Chinese medicine. Basically, ginkgo leaves contain two main groups of compounds: flavonoids and terpenes (diterpenes and sesquiterpenes). These compounds are the basis for its therapeutic actions.

Ginkgo's most powerful effect is on the circulating system. Ginkgo flavenoids directly dilates the micro-capillaries, which increases blood circulation. Ginkgo Biloba reduces capillary permeability and has notable anit-oedematous and anti-varicose effect, as well as nutritive action on connective tissue, increasing the synthesis of collagen along the vessel walls. Ginkgo biloba is an anti-inflammatory vein tonic agent.

Studies carried out showed that ginkgo extracts were more effective than β-carotene and vitamin E to reduce UV-induced oxidative stress in epidermal cells It furthermore increases the creation of fibroblast, collagen and extra cellular fibronectin.

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Glutathione Detoxifying Solution plays an important role in cell protection during ageing, acting both as an antioxidant and a de-toxifying agent.
Glutathione's ability to inhibit melanin synthesis makes it an essential component of melasma and de-pigmentation.

Glutathione (GSH) is a small molecule composed of 3 amino acids, cysteine, glutamic acid and glycine. It is a powerful antioxidant found within every cell protecting our cells from free radicals.

This active substance plays a role in nutrient the regulation of cellular events including gene expression, DNA and protein synthesis and repair, cell growth, and immune response, metabolism of toxins and carcinogens, enhancement of the immune system, and prevention of fat oxidation. It is involved in detoxification, binding itself to toxins such as heavy metals, chemical pollutants and carcinogens and transforming them into a form which can be easily flushed out of the body.

The body produces and stores the largest amounts of GSH in the liver, where it is used to detoxify harmful compounds. GSH levels decline with age, and a lack of glutathione has been shown to leave the body more vulnerable to damage by free radicals, thus speeding up aging processes. Glutathione neutralizes damaging free radicals and peroxide molecules, and recharges oxidized vitamin C and E so that the body may reuse it.

Glutathione has also been implicated in skin lightening. Studies show evidence of its involvement in the melanogenic pathway and its anti-melanogenic effect.

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Glycolic Acid
Glycolic Acid is the most commonly used form of Alpha Hydroxy Acids (AHAs), which are a group of naturally occurring acids derived from certain plants and fruits. It stimulates new growth of skin, collagen and elastin. As well as working to diminish brown spots and hyperpigmentation, it also reduces fine lines, wrinkles, acne, scars and other signs of ageing.
Glycolic Acid Brightening Solution prevents dead cells from clumping together, thus increasing cell turnover. The skin appears bright and rejuvenated, reflecting a healthy glow.

Glycolic Acid is considered to decrease the stratum corneum barrier and increase the penetration of topical agents; it works by stimulating new growth of skin and collagen and has an exfoliant action, once applied glycolic acid reacts with the upper layer of the epidermis, weakening the binding properties of the lipids that hold the dead skin cells together. Furthermore it stimulates glycos-aminos-glycans like hyaluronic acid. The result is a much-smoother skin surface and a more youthful appearance.

Another benefit is glycolic acid's ability to draw moisturizers into the newly-exfoliated skin surface. Glycolic Acid reduces the appearance of fine lines and wrinkles, age spots as well as improves sun-damaged skin. When used in combination with polyvitamins, Glycolic Acid is also useful for reducing stretch marks.

AHAs also help to unclog pores and thus decrease the tendency for acne to develop. A recent study indicated an additive inhibitory effect of glycolic acid on melanin synthesis through tyrosinase activity in melanoma cells, so it is effective for treatments of hyper-pigmentations.

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Hyaluronic Acid
Pure, non-crosslinked Hyaluronic Acid is a highly-effective skin moisturizing agent.
Its particular ability to attract and bind water molecules serves to moisturize the skin and maintain the elasticity of dermal and epidermal tissues. When applied to the skin, Hyaluronic Acid forms a viscoelastic film, replicating its natural function of retaining water in the intercellular matrix of dermal connective tissues. This makes Hyaluronic Acid Wrinkle Smoothing Gel an ideal moisture base, facilitating the delivery of other agents to the skin. An interesting solution for Virtual Mesotherapy recommended for treating wrinkled, tired, sun-damaged and dried-out skin.

In combination with vitamins, Hyaluronic Acid not only helps to prevent signs of ageing, but also works to treat them

Hyaluronic acid offers an effective way to fight against the effects of reduced levels of hyaluronic acid. It is distributed widely throughout connective and plentiful in our bodies when we are born, but its levels gradually decline over time. This reduction in levels is a big part of the aging process, loss of elasticity in the skin that manifests itself in wrinkles.

Hyaluronic acid fills the space between collagen and elastin fibers. The role of hyaluronic acid in skin is to provide a mechanism of transport of essential nutrients from the bloodstream to living skin cells, hydrate the skin by holding in water and to contribute to dermis renewal and elimination of harmful compounds from the skin. It is capable of protecting the skin against ultraviolet irradiation due to its free radical scavenging properties. Hyaluronic acid also acts on angiogenesis by supporting the proliferation of endothelial cells and thus allowing better cutaneous vascularization.

Non reticular hyaluronic acid is a linear polysaccharide identical to the conjunctive tissue hyaluronic acid. It belongs to the family of the glycosaminoglycans (Gags) or mucopolysaccharides. Its viscosity and molecular weight is extremely close to natural hyaluronic acid and enables it to integrate perfectly into the tissue.

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Hyaluronidase is a protean enzyme especially effective in treating the fibrosis associated to cellulite.
This active ingredient prevents the hyperpolymerization of glycosaminoglycans responsible for water retention, acting directly to remove the retained liquid and reduce the adipocytes volume.

Hyaluronidase is particularly suitable for treating cellulite because it is an active ingredient that attacks the fibrosis associated to this problem.

Its mechanism of action is to prevent the hyperpolymerization of glycosaminoglycans responsible for water retention. Hyaluronidase depolymerises sulfuric chondroitin and hyaluronic acid from the ground substance of connective tissue. Also enhances cellular exchange in triglycerides accumulated within adipocytes.

The result of its action is the removal of retained fluids and the reduction of the adipocytes volume, being that triglycerides accumulated there become free fatty acids and glycerol, elements that cover the energy requirements of the organism. Furthermore, hyaluronidase facilitates removal of intra-dermal water bags and promotes the penetration of other active substances through the skin.

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In its natural form in the body, L-Carnitine is responsible for metabolizing fat. After breaking down the stored fat, it mobilizes the fatty acids into the bloodstream, attaching itself to them and carrying them to the area of the cell that converts fat to energy. L-Carnitine Fat Carrier Solution is essential for optimal fat burning.

L-Carnitine exists naturally in the body and is an essential cofactor of acid metabolism of lipids. The best known function of carnitine is its essential role in transporting longchain fatty acids into mitochondria for boxidation, thus being of fundamental importance in lipid catabolism and energy production.

Besides this main action, carnitine has other physiological roles, namely detoxification of non metabolizable acyl residues, general buffering of the acylCoA to CoA ratio, and the shuttling of the acyl groups of acylCoAs, such as peroxisomes, cytosol and mitochondria. All these functions are mediated by a group of carnitine acyltransferases, enzymes specific for the acyl- chain lenghts.

According to some authors, carnitine and its esters protect cells from oxidative damage both by inhibiting free radical propagation and by contributing to repair the oxidized membrane phospholipids. Since the fat burning is such a major source of muscular energy, deficiencies in L-Carnitine are manifested as low energy levels and muscular weakness.

On the basis of the multiple functions described above, carnitine represents a precious aid in the treatment of cellulitis, condition where an alteration of the microcirculation affects the normal functionality of adipocytes, which start to synthesize and accumulate excessive amounts of triglycerides.

The action of carnitine is particularly valuable since it not only promotes lipid catabolism, but also helps in detoxifying and regenerating cells, restoring the physiological functionality of the dermis.

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Organic Silica
A structural element of connective tissue, Organic Silica hydrates, renews and regenerates cells. It stimulates and regulates fibroblast proliferation, enhances collagen synthesis and promotes the regeneration of elastic fibres.

INMED Organic Silica Drainage & Regeneration Solution smoothes, tones and lifts the skin, slowing down the ageing process. It's an interesting solution for Virtual Mesotherapy that restores strength, flexibility and elasticity to the collagen and elastin of connective tissues.

It is a structural component of the connective tissue, forming part of important macro-molecules as elastin and collagen. At this tissue level it induces the control and proliferation of fibroblasts and favours the regeneration of elastic and caliginous fibres.

It binds moisture in the epidermis, thus firming and strengthening the skin. It is also known to act as an anti- oxidant to actively prevent the acceleration of premature aging. It is used when a positive effect on the sustaining skin tissue is desired, for reduction and prevention of the effects of coetaneous aging, for destroying free radicals, and for moisturizing. Silica stimulates and regulates fibroblast mitosis. The lack of silicium implies de-structuring of connective tissue.

In the microcirculation, it modifies venous capillary and lymphatic permeability and, in the fatty tissue it stimulates cAMP synthesis as well as triglyceride hydrolysis. Silicium normalizes cellular metabolism, is a tissue re- generator, and aids in the reduction of cellulite. Organic silica acts as a regulator of cellular metabolisms and cell division

Organic Silica & DMAE
An all-in-one facelift and anti-ageing treatment that combines two powerful rejuvenating agents.

Organic Silica & DMAE immediately tones and smoothes the skin, protecting it against free radicals. Organic Silica & DMAE Regenerating & Firming Solution is effective not just on the face, but also for treating sagging skin on the arms, abdomen, legs and buttocks.

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Naturally abundant in cell membranes, the Phosphatidylcholine breaks down the fat stored in fat cells.
Phosphatidylcholine Lipolytic Solution emulsifies the fat, allowing it to be absorbed into the bloodstream and transported. This makes it the ideal solution for eliminating unattractive, localizedlocalized adiposities from the Virtual Mesotherapy.

Polyunsaturated Phosphatidylcholine is a liquid form of lecithin, which is an enzyme naturally produced in our body. It is the major component of all cell membranes and the lipoproteins that circulate in the blood. It plays an important role in intra and extra cellular metabolic transpor.

Phosphatidylcholine facilitates the emulsification of fat into the tiniest particles, enabling the absorption and transportation of fat. After administration, phosphatidylcholine induces an enzymatic reaction, which leads to the dissolution of fat by producing an emulsion of nano-sized monoglycerides that is transported into the liver and metabolized by beta-oxidation.

Lipolysis is not a replacement for plastic surgery but a very effective therapy to reduce smaller fat areas. Contains sodium deoxycholate.

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Polyvitamins Nutritive Solution is a powerful vitamin complex that delivers deep dermo-nutrition. It supplies essential energizing elements that stimulate the skin cells' natural processes.

Skin's texture is smoothed by this highly antioxidant cocktail, balancing cutanous nutritional deficiencies caused by external and internal factors. The vitamins A, C, E combined with B-Complex fight against devitalized dermal appearance.

Vitamins play a very important role in maintaining the health of the skin. Furthermore, deficiencies of some vitamins are particularly detrimental to the skin and may result in skin diseases and/or accelerated aging.

Polyvitamins Nutritive Solution provides essential energizing elements that stimulate the skin cells natural processes and promotes healthy skin.
These powerful vitamins cocktail offers various benefits to the skin as stimulation of collagen synthesis; dermo-nutrition; refinement of the skin surface; anti-inflammatory effects; antioxidant effects, particularly appreciated since free radicals generated by UV light or pollutants are effectively neutralized and no longer able to damage skin cells; skin-lightening effects or vasodilator effects, enhancing blood circulation of the scalp and stimulating the metabolism of hair follicles.

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Rutin & Melilot Extract
Rutin & Melilot Extract Toning Solution combines melilot extract with rutin, a bioflavanoid also known as vitamin P. The blend of two active ingredients reduces both the fragility and permeability of blood vessels, by means of vasoconstriction.
This ingenious mixture prevents vitamin C from being destroyed in the body due to oxidation, while simultaneously combating collagen loss. It is also used to improve local circulation.

The beneficial effects of the mixture of the active in- gredients of Rutin & Meliot Extract are cantered on the lymphatic and venous levels, essential for every cellulite treatment.

Rutin is a phenolic antioxidant and has been demonstrated to scavenge superoxide radicals. Rutin has antioxidant, anti-inflammatory, anticarcinogenic, antithrombotic, cytoprotective and vasoprotective activities.

This active substance has significant efficacy in diminihing the venous edema which is an early sign of chronic venous disease of the leg. It helps strengthen capillaries, protects against some toxins and has anti-inflammatory effects.

Melilot can help to treat varicose veins and reduce the risk of phlebitis and thrombosis. Melilot contains coumarins, which is converted to dicoumarol, a powerful anti- coagulant. It reduces inflammation and swelling and has wound healing properties.

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Sodium Pyvurate
The regenerating and energizing properties of Sodium Pyruvate make it ideal for use in facial and body treatments.

It stimulates not only collagen synthesis but also fibroblast activity. When combined with regenerating agents such as organic silica or Asian centella, Sodium Pyruvate Stimulating Solution can be used to treat a variety of complaints including skin ageing, stretch marks and hair loss. It has also been shown to accelerate lipolysis, an essential property of many cellulite cocktail.

The sodium pyruvate is a stable salt of the pyruvic acid that occurs naturally in the body and is a nutrient that plays an essential role in the process controlling the production of energy.

Pyruvic acid is used by the organism for the synthesis of ami- no acids, whereas pyruvate is used as complement to enhance weight loss. Sodium pyruvate increases the energy available for muscles, which is translated in a higher rate of burned calories and less fat stored.

It has also been demonstrated that the sodium pyruvate in particular, stimulates the synthesis of collagen in the skin. For this reason, it is considered an excellent energy substrate with interesting applications in the treatment of the coetaneous anti-aging, striae, alopecia, etc.

Other studies suggest that the pyruvate acts as antioxidant, thus contributing to the reduction of the damage by free radicals to the body

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Trace Elements
Trace Elements are essential for balancing the skin’s natural functions and maintaining a youthful appearance. Trace Elements Balancing Solution is unique mixture of Zinc, Selenium, Copper, Manganese and Chrom. Together these actives achieve a perfect dermal equilibrium and normalization by improving the skin’s bio-chemical parameters.

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Vitamin A
Nutritive Solution
Vitamin A or Retinol works as an antioxidant for the skin, disarming free radicals that cause tissue and cell damage. Wrinkles and lines are gradually smoothed, moisture and elasticity improved, the complexion glows and sun damage is diminished. Vitamin A increases the skin's cell turnover, while also boosting collagen, resulting in a more youthful overall appearance.

As well as working to diminish stretch marks, Vitamin A assists the skin's natural healing processes.

This vitamin and its derivatives have displayed beneficial effects in controlling acne and in reversing skin damage caused by environmental factors.

Vitamin A works as an antioxidant on the skin, it disarms free radicals that cause tissue and cellular damage.

Wrinkles and lines are gradually smoothed, moisture and elasticity increase, the complexion glows and sun damage is diminished. It increases the skin's cell turnover, and increases collagen giving a more youthful appearance.

Vitamin A plays an important role in RNA synthesis which produces new and healthy cells in skin. The epidermis is especially sensitive to vitamin A deficiencies since its basal layer continually generates new cells that keratinize and become the horny layer, the protective barrier. As a result of deficiencies, these cells prematurely die, harden, and plug the oil sacs and pores. Retinol exfoliates and unclogs pores; it acts on skin's density and suppleness by regulating keratinizing and healing process.

It helps to restore damaged skin and improve the condition of rough and dry skin or skin with abnormal keratinization. This effect is based upon the action that vitamin A carries out on the basal stratum of the epidermis. Indeed, various studies have shown that applying the vitamin A locally achieves an increase in the mitotic activity of about 30%. By increasing cell turnover, dull surface cells are shed more quickly.

Vitamin A and its derivatives also have shown beneficial effects in controlling acne, psoriasis, neoplastic processes, and most recently, reversal in extrinsically aged skin.

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Vitamin C
Vitamin C is a very effective antioxidant that neutralizes free radicals the unstable molecules that age the skin as a result of pollution, smoking and exposure to the sun. Vitamin C Revitalizing & Antioxidant Solution inhibits melanin, stimulates growth of the hydro-lipid film and enhances collagen synthesis, an important skin protein that strengthens the structural support and elasticity of the skin. This solution is used mainly to treat and prevent photoageing, uneven complexions and for helping the skin to fight wrinkles.

Ascorbic acid is one of the main non-enzymatic, water-soluble antioxidant. Vitamin C is required for the synthesis of collagen, an important structural component of blood vessels, tendons, ligaments and bones.

In addition, vitamin C is required for the synthesis of carnitine, a small molecule that is essential for the transport of fat to cellular organelles called mitochondria, for conversion to energy.

It plays a critical role in dermal construction, stimulating collagen synthesis of dermal fibroblasts. This is thought to occur as a result of ascorbate directly stimulating collagen synthesis, directly and specifically activating collagen gene regulation both by increasing the transcription rate and stabilizing procollagen messenger RNA, thus genetically signaling collagen synthesis. Another mechanism is the initiation of lipid peroxidation, which leads to an increase in a by-product, which stimulates collagen gene expression.

In addition, ascorbic acid is necessary to form lysyl hydroxylase, an enzyme necessary for cross-linking one collagen molecule to another, providing tissue strength.

The topic use of ascorbic acid prevents and treats photo-ageing. UV light exposure depletes up to two thirds of coetaneous ascorbic acid stores.

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